Natural source: polygnum cuspidatum
Trans-resveratrol is the most bio active form available. Resveratol is a potent antioxidant which inhibits angiogenesis and carcinogenesis, is antiviral against herpes, and has phytoestrogen activity. SEA's trans resveratrol is isolated from the root of polygnum cuspidatum.
Resveratrol has been shown to exert some anti-inflammatory effect on cells in culture, either inhibiting the production of PGE-2, cytokines, chemokines, adhesion molecules, or other molecules involved in the inflammatory process. Topical application of resveratrol has been found to significantly inhibit UVB-mediated induction of COX-2 and ODC enzyme activities and protein expression of ODC, which are well established markers for tumor promotion. Resveratrol further seems to inhibit the UVB-mediated increase of lipid peroxidation, a marker of oxidative stress.
Long-term studies have demonstrated that topical application with resveratrol (both pre- and post treatment) results in inhibition of UVB induced tumor incidence and delay in the onset of skin tumorigenesis. The post treatment of resveratrol imparted equal protection to the pretreatment, suggesting that resveratrol-mediated responses may not be sunscreen effects.
Athar M, Back JH, Tang X, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007;224:274.
Trans resveratrol has been shown to be the more bioactive of the reservatrol isomers as such a lower usage is recommended 0.5-1 %.
Appearance: White- cream colored powder
Solubility: soluble in ETOH [ ethanol ] DMSO and DMF, ethyl ether,
Slightly soluble in Water < 100ug/ml.,
pH: No data
Storage: Store away from heat, light and moisture Do not freeze.
Usage: clinical trials produce effects at 0.01% at present an upper limit has not been established. However based on herpes studies:
12.5 and 25% resveratrol cream effectively suppressed lesion formation. The skin of resveratrol-treated animals showed no apparent dermal toxicity such as erythema, scaling, crusting, lichenification, or excoriation. These studies demonstrate that topically applied resveratrol inhibits HSV lesion formation in the skin of mice.
Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice.
Resveratrol protects mitochondria against oxidative stress
Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?
Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites.
Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin